THE EFFECT OF CLINICAL CHARACTERISTICS OF TB PATIENTS ON THE INCIDENCE OF MDR TB AT PROF. DR MARGONO SOEKARJO PURWOKERTO HOSPITAL

Abstrak

ABSTRACT

Background: MDR TB is drug-resistant tuberculosis caused by Mycobacterium tuberculosis that is resistant to rifampicin (RIF) and Isoniazid (INH) which are the most effective first-line anti-TB drugs to fight and eliminate Mycobacterium tuberculosis, so these drugs are often used as monotherapy (administration of only one type of OAT) and short therapy. Objective: This study aims to determine the effect of clinical characteristics in TB patients on the incidence of MDR TB in the Pulmonary Clinic of Margono Soekarjo Purwokerto Hospital. Methods: Descriptive analysis research with cross sectional study design using sampling technique used was total sampling of 62 patients. Data was taken by looking at the patient's medical record. Statistical data analysis using univariate test and bivariate chi square test to identify clinical characteristics that affect the incidence of MDR TB at Margono Soekarjo Purwokerto Hospital. Results: The results showed that there was an influence of clinical characteristics, namely previous TB history on the incidence of MDR TB with a p value of 0.010, while the clinical characteristics that influenced the incidence of MDR TB were 0.010.  Conclusion: the clinical characteristics that most influence the incidence of MDR TB are patients with a history of previous TB disease. So it is expected that stricter monitoring of patients with this history is needed to reduce the prevalence of MDR TB in Indonesia.