RELATIONSHIP BETWEEN ANTERIOR CHAMBER DEPTH, AXIAL LENGTH, AND LENS THICKNESS WITH ENDOTHELIN-1 IN ADOLESCENT MYOPIA

Abstrak

Objective:This study aimed to investigate the relationship between anterior chamber depth (ACD), axial length (AL), and lens thickness (LT) with serum endothelin-1 (ET-1) levels in adolescent patients with myopia.Methods:A cross-sectional analysis was conducted on 60 adolescents aged 10–19 years with myopia (≥ -0.5 D) at RS Prof. Chairuddin Panusunan Lubis from August 2024 to February 2025. Ocular biometric parameters (ACD, AL, LT) were measured using A-scan ultrasonography, and serum ET-1 levels were quantified using ELISA. Statistical tests included ANOVA and Pearson/Spearman correlation analyses.Results:A significant increase in axial length was observed with myopia severity (p < 0.001). No consistent differences in ACD and LT were found across severity groups, except for a significant variation in LT in the left eye (p = 0.047). ET-1 levels were inversely correlated with AL (r = -0.271, p = 0.036), with stronger inverse correlation in mild myopia (r = -0.618, p = 0.004) and a positive correlation in moderate myopia (r = 0.600, p = 0.005). No significant correlations were found between ET-1 and ACD or LT.Conclusion:The study reveals a significant inverse relationship between AL and ET-1 levels in adolescent myopia, suggesting potential vascular involvement in myopia progression. ET-1 may serve as a promising biomarker for early detection and monitoring of myopic changes.